Do we need to worry about resistance?
Overview
Learning Objectives:
- Describe the broad biological and evolutionary processes by which antiviral resistance can emerge in RNA viruses.
- Outline mechanisms of antiviral resistance development in coronaviruses with nucleoside analogues, drawing on evidence from human COVID-19 literature.
- Describe the implications of subtherapeutic dosing, prolonged treatment, and immunocompromised states for driving antiviral resistance in feline coronaviruses.
- Evaluate findings from a rapid risk assessment tool regarding the likelihood of clinically significant antiviral resistance emergence in feline coronaviruses.
- Discuss strategies to minimise the risk of antiviral resistance development in FIP treatment protocols.