FIP diagnostics: PCR, ICC, IHC and the evolving role of test performance in the era of machine learning
Overview
- Determine when FCoV PCR, ICC, and IHC should be considered based on clinical presentation and sample accessibility
- Interpret the sensitivity and specificity of PCR, ICC, and IHC in the literature, and explain how these are influenced by sample type and disease presentation
- Select appropriate sample types for each diagnostic modality and recognise key practical limitations, including effects of sample handling, transport, and storage
- Evaluate how the availability of effective treatment has shifted diagnostic priorities, particularly the balance between maximising specificity versus avoiding false negatives and diagnostic delay
- Recognise the emerging role of data-driven approaches (including machine learning) in FIP diagnostics, and their potential to influence future interpretation and clinical decision-making